Related Experiment Video
Updated: Apr 8, 2026
07:22
A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
Published on: March 14, 2025
1.4K
Optimal management of digital ulcers in systemic sclerosis
Shawn Abraham1, Virginia Steen1
1Division of Rheumatology, immunology, and Allergy, MedStar Georgetown University Hospital, Washington, DC, USA.
Therapeutics and Clinical Risk Management
|June 26, 2015
Summary
Systemic sclerosis often causes painful Raynaud's phenomenon and digital ulcers. While no FDA-approved drugs exist, various treatments can help heal existing ulcers and prevent new ones.
Area of Science:
- Rheumatology
- Dermatology
- Vascular Medicine
Background:
- Systemic sclerosis is associated with Raynaud's phenomenon and digital ulcerations.
- These conditions cause pain, morbidity, and impaired hand function.
- Current treatment landscape lacks FDA-approved medications specifically for digital ulcerations in the US.
Purpose of the Study:
- To review published data on therapeutic options for digital ulcerations in systemic sclerosis.
- To discuss pharmacologic and nonpharmacologic treatments.
- To provide an overview of current management strategies.
Main Methods:
- Literature review of published clinical trials and studies.
- Analysis of data on healing and prevention of digital ulcers.
- Synthesis of information on various treatment modalities.
Main Results:
- Clinical trials support the efficacy of certain pharmacologic and nonpharmacologic interventions.
- These treatments aid in the healing of existing digital ulcers.
- Preventive strategies can reduce the formation of new digital ulcers.
Conclusions:
- Effective management of digital ulcerations in systemic sclerosis involves a combination of approaches.
- Further research may lead to FDA-approved therapies.
- Optimizing hand function and reducing morbidity are key treatment goals.
Related Concept Videos
01:26Peripheral Artery Disease IV: Nursing Management
621
The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
621
01:26Peptic Ulcer Disease IV: Management
668
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
668
01:26Atherosclerosis III: Management
593
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
593
01:27Peripheral Artery Disease III: Interprofessional Care
594
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
594
01:23Atherosclerosis IV: Nursing Management
579
Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
579
01:26Varicose Veins II: Diagnostic Studies and Interprofessional Care
296
Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
296