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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
Published on: July 24, 2019
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Developments in impulse control behaviours of Parkinson's disease
Mateusz Zurowski1, Jonathan Darcy O'Brien
1aDepartment of Psychiatry, Toronto Western Hospital, University Health Network bDepartment of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Current Opinion in Neurology
|June 26, 2015
Summary
Impulse control behaviours (ICBs) in Parkinson's disease patients are common and linked to risk factors. Reducing dopamine agonists is the primary treatment, with other therapies showing potential.
Area of Science:
- Neurology
- Neuroscience
- Psychiatry
Background:
- Impulse control behaviours (ICBs) are a frequent comorbidity in Parkinson's disease (PD).
- ICBs encompass impulse control disorders, dopamine dysregulation syndrome, and punding.
- Understanding impulsivity and its risk factors in PD is an evolving field.
Purpose of the Study:
- To review the understanding of impulsivity in Parkinson's disease.
- To assess risk factors contributing to the development of ICBs.
- To discuss the appropriate management of ICBs in PD patients.
Main Methods:
- Review of current literature on impulse control behaviours in Parkinson's disease.
- Analysis of demographic, clinical, and biochemical risk factors.
- Evaluation of treatment strategies for ICBs.
Main Results:
- Impulsivity is common in untreated Parkinson's disease patients.
- The incidence of ICBs correlates with specific risk factors.
- Current treatments focus on reducing dopamine agonists, with cognitive behavioural therapy and repetitive transcranial magnetic stimulation also considered.
Conclusions:
- Dopamine agonist dose reduction is the primary treatment for ICBs in Parkinson's disease.
- Alternative dopaminergic treatments exist but may cause withdrawal symptoms.
- Emerging therapies show promise but require further data for regular use.
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