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Updated: Apr 8, 2026
Evaluating Targeting Accuracy in the Focal Plane for an Ultrasound-guided High-intensity Focused Ultrasound Phased-array System
Published on: March 6, 2019
Treatment Time or Convection Volume in HDF: What Drives the Reduced Mortality Risk?
Camiel L M de Roij van Zuijdewijn1, Menso J Nubé, Piet M ter Wee
1Department of Nephrology, VU University Medical Center, Amsterdam, The Netherlands.
Background/Aims:
Treatment time is associated with survival in hemodialysis (HD) patients and with convection volume in hemodiafiltration (HDF) patients. High-volume HDF is associated with improved survival. Therefore, we investigated whether this survival benefit is explained by treatment time.
Methods:
Participants were subdivided into four groups: HD and tertiles of convection volume in HDF. Three Cox regression models were fitted to calculate hazard ratios (HRs) for mortality of HDF subgroups versus HD: (1) crude, (2) adjusted for confounders, (3) model 2 plus mean treatment time. As the only difference between the latter models is treatment time, any change in HRs is due to this variable.
Results:
114/700 analyzed individuals were treated with high-volume HDF. HRs of high-volume HDF are 0.61, 0.62 and 0.64 in the three models, respectively (p values <0.05). Confidence intervals of models 2 and 3 overlap.
Conclusion:
The survival benefit of high-volume HDF over HD is independent of treatment time.
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