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Updated: Apr 8, 2026

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Engineering structure and function using thermoresponsive biopolymers.

Martha K Pastuszka¹, J Andrew MacKay¹

¹Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA, USA.

Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology

|June 27, 2015

Summary

This summary is machine-generated.

Biological macromolecules like DNA, polysaccharides, and proteins can self-assemble into nanostructures. Temperature changes trigger this organization, offering precise control for potential clinical applications.

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Area of Science:

Biotechnology
Materials Science
Nanotechnology

Background:

Self-assembly offers precise control over nanoscale materials, organizing small building blocks into functional structures.
Environmental cues, like temperature changes, can initiate the formation of macromolecular assemblies.
Biological polymers provide superior control over building block composition and may offer biodegradation advantages for clinical use.

Purpose of the Study:

To review the literature on temperature-dependent nano-assembly of biological macromolecules.
To summarize the physical properties of these self-assembled nanostructures.
To discuss future research directions in this field.

Main Methods:

Focus article review of existing scientific literature.
Analysis of temperature-triggered self-assembly mechanisms in biological polymers.
Summary of physical characteristics of DNA, polysaccharide, and protein nanostructures.

Main Results:

DNA, polysaccharides, and proteins can be engineered to self-assemble into nanostructures.
Temperature is a key environmental cue that drives the organization of these biological macromolecules.
These self-assembled nanostructures exhibit diverse compositions and functions.

Conclusions:

Biological macromolecules offer a powerful platform for creating precisely controlled nanostructures via self-assembly.
Temperature-dependent self-assembly of DNA, polysaccharides, and proteins holds significant promise for various applications, including clinical ones.
Further research is needed to fully explore the potential and optimize the properties of these bio-inspired nanomaterials.