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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
Published on: December 19, 2019
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Drug-induced skin reactions: a pathologist viewpoint
Mahmoud Rezk Abdelwahed Hussein1
1a Department of Pathology, Faculty of Medicine , Assuit University Hospitals, Assuit University , Assuit , Egypt.
Cutaneous and Ocular Toxicology
|June 27, 2015
Summary
Cutaneous drug reactions, common in hospitalized patients, present diagnostic challenges due to varied mechanisms and presentations. This study classifies histomorphologic reactions to aid in diagnosing these adverse drug effects.
Area of Science:
- Dermatology
- Pharmacology
- Pathology
Background:
- Cutaneous drug reactions (CDRs) are frequent adverse events in hospitalized patients, affecting 2-3%.
- These reactions involve both immunologic and non-immunologic pathways.
- CDRs often mimic other dermatoses, complicating diagnosis.
Purpose of the Study:
- To classify histomorphologic reactions to drugs.
- To assist in the morphologic diagnosis of cutaneous drug eruptions.
Main Methods:
- Review of clinical and histological features of cutaneous drug reactions.
- Classification of histomorphologic patterns associated with drug intake.
Main Results:
- Significant clinical indicators include drug history, atypical features, and resolution upon drug withdrawal.
- Histological clues encompass mixed patterns, apoptotic keratinocytes, dermal/epidermal eosinophils, papillary edema, and erythrocyte extravasation.
- No single feature definitively identifies drug eruptions.
Conclusions:
- Cutaneous drug reactions exhibit diverse clinical and histological presentations.
- A systematic classification of histomorphologic patterns can aid in diagnosis.
- Further research may refine diagnostic criteria for drug-induced skin conditions.
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