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Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Superselective pseudo-continuous arterial spin labeling angiography.

Ulf Jensen-Kondering1, Thomas Lindner1, Matthias J P van Osch2

  • 1Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein, Kiel, Germany.

European Journal of Radiology
|June 27, 2015
PubMed
Summary
This summary is machine-generated.

A new non-contrast magnetic resonance angiography (MRA) using superselective pseudo-continuous arterial spin labeling (ASL) visualizes intracranial arteries effectively. This advanced ASL MRA offers comparable image quality to time-of-flight MRA and provides additional insights into arteriovenous malformations.

Keywords:
Arterial spin labelingArterio-venous malformationMR angiographyNon-contrast enhancedSelective ASL

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Area of Science:

  • Neuroradiology
  • Medical Imaging
  • Vascular Imaging

Background:

  • Time-of-flight (TOF) magnetic resonance angiography (MRA) is a standard for intracranial artery assessment.
  • Non-contrast enhanced MRA techniques are desirable to reduce risks associated with gadolinium contrast agents.

Purpose of the Study:

  • To evaluate a novel non-contrast superselective pseudo-continuous arterial spin labeling (ASL) MRA for intracranial artery morphology.
  • To compare the diagnostic utility of ASL MRA against conventional TOF MRA.

Main Methods:

  • Superselective ASL angiographies of carotid and basilar arteries were performed in volunteers on a 1.5T system.
  • TOF MRA datasets were acquired for comparison.
  • Radiologists assessed arterial segment depiction and delineation.
  • ASL MRA was applied to two patients with arteriovenous malformations (AVMs).

Main Results:

  • Both ASL MRA and TOF MRA demonstrated continuous depiction of intracranial arteries and their segments with high inter-reader agreement.
  • ASL MRA provided similar information on AVM size and shape compared to TOF MRA.
  • ASL MRA revealed detailed blood supply to AVMs, confirmed by digital subtraction angiography.

Conclusions:

  • Superselective ASL MRA effectively visualizes intracranial arterial trees, providing macrovascular and flow territory information.
  • ASL MRA achieves image quality comparable to TOF MRA for identifying and delineating arterial segments.
  • Initial use in AVM patients highlights ASL MRA's potential for additional diagnostic information on feeding vessels and blood supply.