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Arginine addiction in AML

William Plunkett1

  • 1UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER.

Blood
|June 27, 2015
PubMed

Abstract:

In this issue of Blood, Miraki-Moud et al demonstrate that the majority of acute myeloid leukemias (AMLs) have low expression of argininosuccinate synthetase-1 (ASS1), rendering AML cell lines and primary AML blasts dependent on exogenous arginine and sensitized to arginine deprivation.

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