Related Experiment Video

Updated: Apr 8, 2026

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
04:41

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

8.8K

Meta-Analysis of miR-146a Polymorphisms Association with Coronary Artery Diseases and Ischemic Stroke

Mei-Hua Bao1, Yan Xiao2, Qing-Song Zhang3

  • 1Department of Anatomy, Histology and Embryology, Changsha Medical University, Changsha 410219, China. mhbao78@163.com.

International Journal of Molecular Sciences
|June 27, 2015
PubMed

Insights

The miR-146a rs2910164 polymorphism is linked to reduced coronary artery disease (CAD) risk. This single nucleotide polymorphism (SNP) shows no significant association with ischemic stroke (IS) susceptibility overall.

Area of Science:

  • Genetics and Molecular Biology
  • Cardiovascular Diseases
  • Neurology

Background:

  • Coronary artery disease (CAD) and ischemic stroke (IS) are major causes of mortality, both stemming from atherosclerosis.
  • MicroRNA-146a (miR-146a) plays a role in the progression of CAD and IS.
  • A specific single nucleotide polymorphism (SNP), rs2910164, in the miR-146a precursor has been investigated for its association with CAD and IS risk, but findings remain inconsistent.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the association between the miR-146a rs2910164 polymorphism and the risk of CAD and IS.
  • To clarify the conflicting results from previous studies regarding rs2910164 and its impact on atherosclerosis-related disease susceptibility.

Main Methods:

  • A systematic literature search was performed across major databases: Pubmed, Embase, Cochrane CENTRAL, CNKI, and CBM.
  • Eight studies comprising 3138 cases and 3097 controls were included in the meta-analysis.
  • Crude odds ratios (ORs) with 95% confidence intervals were calculated using random- or fixed-effect models to assess the strength of association for rs2910164.

Main Results:

  • The rs2910164 polymorphism was significantly associated with a reduced risk of CAD across multiple genetic models (allelic, homozygous, heterozygous, dominant).
  • Individuals with the GG genotype, GG + GC genotype, or G allele showed a lower risk of developing CAD.
  • No significant overall association was found between rs2910164 and IS susceptibility. However, subgroup analyses indicated a potential increased risk in large sample sizes and among Koreans under specific models.

Conclusions:

  • The rs2910164 polymorphism is associated with a decreased risk of coronary artery disease.
  • Rs2910164 is not definitively linked to ischemic stroke risk, despite some subgroup findings.
  • Rs2910164 may serve as a potential predictive marker for CAD susceptibility, but not for IS.

Keywords:
coronary artery diseaseischemic strokemeta-analysismiR-146a polymorphismrs2910164

More Related Videos

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

8.0K

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
16.7K
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
119
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
19.9K