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Related Concept Videos

Measurement of Blood Pressure01:17

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Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a...
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Related Experiment Video

Updated: Apr 8, 2026

Autonomic Function Following Concussion in Youth Athletes: An Exploration of Heart Rate Variability Using 24-hour Recording Methodology
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Syncope in Children and Adolescents.

Khalil Kanjwal1, Hugh Calkins2

  • 1Section of Cardiac Electrophysiology, Johns Hopkins University, Baltimore, MD 21287, USA.

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Pediatric syncope management often relies on adult data. More research is needed for children with recurrent neurocardiogenic syncope (NCS), as current treatments lack proven efficacy.

Keywords:
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Area of Science:

  • Pediatric Cardiology
  • Neurology
  • Clinical Pharmacology

Background:

  • Syncope management in children frequently extrapolates from adult studies.
  • Recurrent syncope in pediatric populations necessitates dedicated research.
  • Neurocardiogenic syncope (NCS) is the leading cause of syncope in both children and adults.

Purpose of the Study:

  • To highlight the need for pediatric-specific syncope research.
  • To address the lack of FDA-approved therapies for NCS.
  • To evaluate the efficacy of pharmacotherapy for NCS in children.

Main Methods:

  • Review of existing literature on syncope management strategies.
  • Analysis of clinical trial data for pharmacotherapy in NCS.
  • Assessment of current treatment guidelines for pediatric syncope.

Main Results:

  • Current syncope management strategies are largely based on adult data.
  • No pharmacotherapy for NCS has demonstrated superiority over placebo in clinical trials.
  • There is a significant gap in FDA-approved treatments for pediatric NCS.

Conclusions:

  • NCS should be viewed as a chronic condition in children.
  • Therapeutic goals for NCS should focus on reducing syncope recurrence.
  • Further research is crucial to develop effective, evidence-based treatments for pediatric syncope.