Swallowable smart pills for local drug delivery: present status and future perspectives

Rosa Goffredo1, Dino Accoto, Eugenio Guglielmelli

  • 1a Università Campus Bio-Medico di Roma, Biomedical Robotics and Biomicrosystems Lab, Via alvaro del portillo 21, Roma, 00128, Italy.

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Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
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