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Plasmonic Colloidosomes as Three-Dimensional SERS Platforms with Enhanced Surface Area for Multiphase Sub-Microliter
Gia Chuong Phan-Quang1, Hiang Kwee Lee1,2, In Yee Phang2
1Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371 (Singapore).
Angewandte Chemie (International Ed. in English)
|June 30, 2015
Summary
We developed advanced plasmonic colloidosomes for ultrasensitive detection of toxins. This novel 3D SERS platform enables high-throughput multiplex sensing with remarkable sensitivity, advancing molecular diagnostics.
Area of Science:
- Materials Science
- Analytical Chemistry
- Nanotechnology
Background:
- Colloidosomes are robust microcapsules with potential for molecular sensing.
- Current colloidosome sensors offer limited qualitative detection for a narrow range of molecules.
Purpose of the Study:
- To develop a highly sensitive and quantitative sensing platform using colloidosomes.
- To create a 3D Surface-Enhanced Raman Spectroscopy (SERS) platform for molecular detection.
Main Methods:
- Construction of plasmonic colloidosomes using silver (Ag) nanocubes.
- Utilizing an emulsion-based approach for creating the 3D SERS platform.
- Testing the platform's sensitivity and performance in quantifying food and industrial toxins.
Main Results:
- The plasmonic colloidosomes demonstrated excellent mechanical robustness and tunable size.
- Achieved ultrasensitive SERS quantitation of toxins at sub-femtomole levels.
- Exhibited over 3000-fold higher SERS sensitivity compared to conventional suspension platforms using minimal sample volumes (0.5 μL).
Conclusions:
- Plasmonic colloidosomes offer a versatile and robust platform for advanced molecular sensing.
- The developed 3D SERS platform enables high-throughput, multiplex molecular sensing across multiple liquid phases.
- This technology significantly enhances the sensitivity and applicability of colloidosome-based sensors.
