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Body composition in acromegaly.

B A Bengtsson1, R J Brummer, S Edén

  • 1Department of Medicine II, Sahlgrenska Hospital, Göteborg, Sweden.

Clinical Endocrinology
|February 1, 1989
PubMed
Summary
This summary is machine-generated.

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Acromegaly patients exhibit significantly higher total body water and potassium levels, with increased body cell mass and extracellular water, but reduced body fat compared to healthy individuals. These body composition changes correlate with disease severity and onset.

Area of Science:

  • Endocrinology
  • Human Physiology
  • Body Composition Analysis

Background:

  • Acromegaly is a hormonal disorder caused by excess growth hormone (GH).
  • Body composition alterations are characteristic of acromegaly but require detailed quantification.

Purpose of the Study:

  • To investigate body composition differences in untreated acromegalic patients compared to healthy controls.
  • To correlate these differences with disease characteristics such as height and hormone levels.

Main Methods:

  • Measured total body potassium (TBK) and total body water (TBW) in 156 untreated acromegalic patients.
  • Predicted normal body weight (BWnorm) from height (BH) and sex using reference population data.
  • Compared patient measurements to predicted values derived from healthy subjects.

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Main Results:

  • Acromegalic patients were significantly taller than controls, with earlier onset associated with greater height.
  • Patients showed significantly higher TBK, TBW, and extracellular water (ECW)/intracellular water (ICW) ratios, and lower body fat (BF) than predicted.
  • Both male and female patients had increased body cell mass (BCM) and ECW, with decreased BF.

Conclusions:

  • Untreated acromegaly leads to distinct body composition changes, including increased water and cell mass with reduced fat.
  • Body composition alterations are linked to GH excess and may serve as indicators of disease status.