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Solid Cancer Incidence in the Techa River Incidence Cohort: 1956-2007
F G Davis1, K L Yu2, D Preston3
1a Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, Illinois;
Radiation Research
|June 30, 2015
Summary
This study on the Techa River Cohort found a significant linear relationship between radiation dose and solid cancer incidence. Radiation exposure likely increased cancer risks for most solid cancers in the cohort.
Area of Science:
- Environmental Health
- Radiation Epidemiology
- Oncology
Background:
- The Techa River Cohort has been studied for radiation exposure effects.
- Previous studies indicated linear dose-response relationships for solid cancers and leukemia (non-CLL).
Purpose of the Study:
- To update cancer risk estimates for the Techa River Cohort using updated dosimetry and extended follow-up.
- To investigate site-specific cancer risks and the influence of smoking.
Main Methods:
- Analysis of 17,435 cohort members with individualized dose estimates from the Techa River Dosimetry System 2009.
- Inclusion of data from 1956 to 2007, with five additional years of follow-up.
- Calculation of cancer risk estimates, adjusted for smoking where applicable.
Main Results:
- A statistically significant linear trend (P = 0.02) was observed for smoking-adjusted all-solid cancer incidence risks.
- An excess relative risk (ERR) of 0.077 per 100 mGy for all solid cancers.
- Statistically significant radiation dose effects were identified for esophageal and uterine cancers (ERR > 0.10 per 100 mGy).
Conclusions:
- Radiation exposure is associated with increased risks for solid cancers in the Techa River Cohort.
- While specific site risks may lack statistical power, a dose-response relationship persists for most solid cancers.
- Esophageal cancer risk was influenced by ethnicity and sex, but not smoking.
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