Polymorphism of hOGG1 Gene and Susceptibility to Malignant Neoplasms in People Affected by Long-Term Low-Dose-Rate...

In the previous study [1], we showed an increased risk of malignant neoplasms in carriers of the minor allele rs1052133*G of the hOGG1 gene who were affected by chronic radiation exposure at a wide range of doses (up to 3507 mGy to the red bone marrow at the Techa River (Southern Urals). The objective of the present study was to assess the contribution of radiation factor to the risk of malignant neoplasm development in persons chronically exposed at the Techa River. For this purpose, we analyzed the background level of genetically determined risk in the general population of unexposed people on the basis of meta-analysis of the world literature data on the search for the association of rs1052133 of the hOGG1 gene with the risk of malignant neoplasm development. At the final stage, the results of the meta-analysis were compared with data on exposed people. The study found that unexposed and exposed carriers of the rs1052133*G allele had a comparable increased risk of developing malignant neoplasms, odds ratio OR = 1.20; 95% confidence interval [1.06-1.35], p = 0.01 and odds ratio OR = 1.38; 95% confidence interval [1.05-1.83], p = 0.023, respectively.