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Updated: Apr 8, 2026

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
Published on: December 4, 2016
A switch-on MRI contrast agent for noninvasive visualization of methylmercury
Gyan Singh1, Kuang-Mei Hsu, Yu-Jen Chen
1Department of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu 300, Taiwan. ymwang@mail.nctu.edu.tw.
Abstract:
This communication presents the first Gd(III)-based T1 MRI contrast agent, o-MeHgGad, for noninvasive visualization of CH3Hg(+). o-MeHgGad showed a relaxivity enhancement of 62% in the presence of 1 equiv. of CH3Hg(+). Moreover, a noticeable contrast enhancement was recorded in the liver, kidney, and intestine of mice exposed to CH3Hg(+). Thus, the newly designed contrast agent has the potential to be used for in vivo bio-imaging of CH3Hg(+) and could be useful for biomedical applications.
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