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Updated: Aug 15, 2026

A Matrigel-Based Tube Formation Assay to Assess the Vasculogenic Activity of Tumor Cells
Published on: September 7, 2011
[Angiogenesis activity of tissues and cells of different malignancies]
1Beijing Institute for Cancer Research.
Abstract:
Cancer cells are able to produce tumor angiogenesis factors (TAF), by which the tumor growth could be maintained. Angiogenetic activity of 12 kinds of cells and tissues with distinct character from different sources were detected by chick embryo chorioallantoic membrane. The results indicated that all the cells and tissues tested showed angiogenetic activity but they differed from one another, some were strong and other weak. Of them, the breast cancer was the strongest. The ascitic tumor didn't show any angiogenetic activity, but it reappeared when the ascitic cells were transformed to solid tumors. The level of angiogenetic activity of tumors was closely related to their biological properties and form of existence.
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