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Updated: Apr 8, 2026
Reliable Isolation of Central Nervous System Microvessels Across Five Vertebrate Groups
Published on: January 12, 2020
Cerebral Small-Vessel Disease in Neuro-Behçet Disease
Sohei Yoshimura1, Tetsuro Ago2, Masatoshi Koga3
1Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.
Background:
Involvement of central nervous system is very common in Behçet disease, known as neuro-Behçet disease (NBD). However, there have been few reports which evaluated stroke-like cerebral small-vessel disease associated with Behçet disease.
Objective:
We evaluated cerebral small-vessel lesions by using magnetic resonance imaging in 2 patients with NBD.
Clinical Cases:
In a 41-year-old woman case, who developed dysarthria and left hemiparesis, diffusion-weighted images (DWI) showed small high-intensity areas in the bilateral internal capsule. The right lesion had a low apparent diffusion coefficient (ADC) value, whereas the left one had a high value. In a 59-year-old woman case, who developed dysarthria and left hemihypesthesia, DWI showed high-intensity areas in the right side of the pons and in the right peduncle of the midbrain. The lesion in the pons had a low ADC value, whereas the lesion in the midbrain had a high value. ADC map may be useful to identify symptomatic lesions in the brain, because only the lesions with low ADC values were symptomatic.
Conclusions:
NBD should be considered in those who had not had any risk factors for ischemic stroke but experienced cerebral small-vessel disease.
