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Updated: Apr 8, 2026
03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
925
PDGFR-α and CD117 Expression Pattern in Esophageal Carcinomas
Mariusz Adam Goscinski1, Stein Gunnar Larsen2, Karl-Erik Giercksky2
1Department of Surgery, The Norwegian Radium Hospital, Oslo University Hospital, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway mariuszg@online.no.
Anticancer Research
|July 1, 2015
Summary
Platelet-derived growth factor receptor (PDGFR-α) and CD117 are present in esophageal cancer cells. Higher PDGFR-α expression correlated with better survival, suggesting potential therapeutic targets.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Esophageal cancer has a low 5-year survival rate despite advanced treatments.
- Previous research explored antibodies and tyrosine kinase inhibitors for cancer therapy.
- Receptor tyrosine kinases PDGFR-α and CD117 are implicated in carcinogenesis.
Purpose of the Study:
- To investigate the expression of PDGFR-α and CD117 in esophageal carcinomas.
- To explore the potential role of these receptors in esophageal cancer progression.
Main Methods:
- Immunohistochemistry was used to examine tissue samples from 52 Norwegian esophagectomy patients.
- Expression levels of PDGFR-α and CD117 were analyzed in different esophageal carcinoma types.
Main Results:
- PDGFR-α and CD117 expression was detected in all esophageal cancer cell samples.
- Squamous cell carcinoma showed higher PDGFR-α immunoreactivity.
- Increased PDGFR-α-positive cells were associated with improved patient survival.
Conclusions:
- PDGFR-α and CD117 likely play significant roles in esophageal cancer progression.
- These receptors may represent future targets for biological anticancer therapies.
- Further validation with larger patient cohorts is warranted.
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