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Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
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P wave dispersion in obsessive-compulsive disorder.

Mustafa F Yavuzkir1, Murad Atmaca2, M Gurkan Gurok2

  • 1Department of Cardiology, School of Medicine, Firat University, Elazig, Turkey.

Indian Journal of Psychiatry
|July 1, 2015
PubMed
Summary

P wave dispersion (Pd), a measure of heart rhythm, is significantly increased in individuals with obsessive-compulsive disorder (OCD). This finding suggests a potential link between OCD and cardiac autonomic nervous system dysfunction.

Keywords:
Autonomous nervous systemP wave dispersionobsessive-compulsive disorder

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Area of Science:

  • Cardiology
  • Psychiatry
  • Autonomic Nervous System Research

Background:

  • P wave dispersion (Pd) quantifies variations in P wave duration on ECG.
  • Pd is linked to anxiety and potential cardiac risks.
  • No prior ECG studies explored Pd in obsessive-compulsive disorder (OCD).

Purpose of the Study:

  • To investigate P wave dispersion (Pd) in patients diagnosed with obsessive-compulsive disorder (OCD).
  • To explore the relationship between Pd and OCD severity.

Main Methods:

  • A case-control study involving 25 OCD patients and 25 healthy controls.
  • Electrocardiography (ECG) was used to measure P wave duration (Pmax and Pmin).
  • The Yale-Brown Obsession and Compulsion Scale (Y-BOCS) assessed OCD severity.

Main Results:

  • OCD patients exhibited significantly higher P wave dispersion (Pd) compared to controls.
  • Pmax was elevated in OCD patients, while Pmin showed no significant difference.
  • A positive correlation was observed between Y-BOCS scores and Pd in OCD patients.

Conclusions:

  • Increased P wave dispersion (Pd) may be associated with obsessive-compulsive disorder (OCD).
  • Findings suggest a potential role for autonomic nervous system dysfunction in OCD.
  • Larger studies are needed to confirm these results and explore treatment effects.