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Manufacture and Drug Delivery Applications of Silk Nanoparticles
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Multiple cues on the physiochemical, mesenchymal, and intracellular trafficking interactions with nanocarriers to

Sang-Woo Kim1, Dongwoo Khang1

  • 1Nanomedicine Laboratory, Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, South Korea.

International Journal of Nanomedicine
|July 1, 2015
PubMed

Insights

Improving cancer treatment involves enhancing nanodrug delivery. This review explores strategies like optimizing nanocarrier biodistribution and using stem cell-conjugated nanotherapeutics to improve tumor targeting and patient quality of life.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Cancer survival rates have improved, but chemotherapy side effects diminish patient quality of life.
  • Current nanodrugs lack tumor-specific targeting due to poor biodistribution and reticuloendothelial system uptake.
  • Enhanced drug delivery is crucial for improving cancer patient outcomes and well-being.

Purpose of the Study:

  • To review physicochemical factors influencing nanocarrier biodistribution for improved tumor targeting.
  • To discuss stem cell-conjugated nanotherapeutics for enhanced tumor searching and growth inhibition.
  • To explore material properties of anticancer nanodrugs for organelle targeting and controlled release.

Main Methods:

  • Literature review of nanocarrier biodistribution and targeting strategies.
  • Analysis of physiochemical factors affecting nanodrug delivery.
  • Discussion of stem cell conjugation and material property modulation for enhanced efficacy.

Main Results:

  • Optimizing nanocarrier physiochemistry can improve biodistribution and tumor targeting.
  • Stem cell conjugation enhances nanotherapeutic tumor-searching capabilities.
  • Tailoring nanodrug material properties allows for targeted delivery and controlled release.

Conclusions:

  • Understanding nanocarrier biodistribution is key to increasing tumor-targeting efficiency.
  • Advanced nanotherapeutic strategies can significantly improve cancer treatment efficacy.
  • Improving nanodrug delivery enhances quality of life for cancer patients undergoing chemotherapy.
Keywords:
anticancer nanodrugscancerintracellular traffickingmesenchymal stem cell

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