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Myocardial Infarction and Stroke Risk in Young Healthy Men Treated with Injectable Testosterone.

Robert S Tan1, Kelly R Cook2, William G Reilly2

  • 1Low T Institute, Dallas, TX 76092, USA ; University of Texas, Houston, TX 77030, USA ; Baylor College of Medicine, Houston, TX 77030, USA ; Michael DeBakey VAMC, Houston, TX 77030, USA ; Opal Medical Clinic, Houston, TX 77098, USA.

International Journal of Endocrinology
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PubMed
Summary
This summary is machine-generated.

Testosterone therapy was associated with significantly lower rates of myocardial infarction (MI) and stroke in young, healthy men. This testosterone treatment showed general safety for this demographic without major cardiovascular risk factors.

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Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Men's Health

Background:

  • Hypogonadism is a condition characterized by low testosterone levels.
  • Testosterone therapy (T) is increasingly prescribed, particularly in younger men.
  • Concerns exist regarding the cardiovascular safety of T in men with hypogonadism.

Purpose of the Study:

  • To investigate the association between testosterone therapy and new myocardial infarction (MI) and stroke events.
  • To evaluate the safety of testosterone treatment in a cohort of young, otherwise healthy men diagnosed with hypogonadism.

Main Methods:

  • Retrospective analysis of electronic medical records from 40 Low T Centers in the US (2009-2014).
  • Inclusion of 19,968 eligible patients receiving testosterone treatment and comparison with non-treated hypogonadal men.
  • Comparison of MI and stroke incidence rates with community-based registries.

Main Results:

  • Testosterone-treated patients had significantly lower incidence rate ratios (IRR) for MI (0.14) and stroke (0.11) compared to non-treated patients (P < 0.0001 for both).
  • No evidence of worsening pre-existing MI or stroke in patients receiving testosterone.
  • No association found between MI events in T-treated patients and testosterone or hematocrit levels.

Conclusions:

  • Testosterone therapy appears generally safe for younger men with hypogonadism and without significant cardiovascular risk factors.
  • The study suggests a potential protective effect of testosterone therapy against new MI and stroke events in this population.
  • Findings support the cautious use of testosterone therapy in select patient groups based on observed safety and efficacy data.