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Updated: Apr 8, 2026

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry
Published on: March 1, 2013
Gene delivery polymer structure-function relationships elucidated via principal component analysis
C J Bishop1, B Abubaker-Sharif, T Guiriba
1The Johns Hopkins University School of Medicine, Department of Biomedical Engineering, Translational Tissue Engineering Center, 400 North Broadway, Baltimore MD, USA. green@jhu.edu.
Abstract:
Principal component analysis was applied to a biomaterial library of poly(beta-amino ester)s, useful for non-viral gene delivery, to elucidate chemical parameters that drive biological function. Correlative relationships and principal components were analyzed between 24 physico-chemical polymer properties and 3 cell-based functional variables in human glioblastoma cells (transfection, uptake, and viability).
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