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Related Experiment Videos

The "hitchhiking effect" revisited.

N L Kaplan1, R R Hudson, C H Langley

  • 1Statistics and Biomathematics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.

Genetics
|December 1, 1989
PubMed
Summary
This summary is machine-generated.

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Ancestral selection at linked loci can reduce neutral genetic diversity through hitchhiking. This effect is pronounced in low crossing over regions, decreasing polymorphic sites in gene samples.

Area of Science:

  • Population genetics
  • Molecular evolution

Background:

  • Selective substitutions at loci linked to neutral sites can impact genetic diversity.
  • The phenomenon, known as hitchhiking, depends on timing, selection strength, and recombination rates.

Purpose of the Study:

  • To develop a population genetic model for hitchhiking's steady-state effect.
  • To analyze hitchhiking's impact on neutral polymorphic sites in finite populations.

Main Methods:

  • Utilized the coalescent process for a random sample of genes.
  • Developed a stochastic, finite population model for linked selection.

Main Results:

  • Hitchhiking significantly reduces the number of neutral polymorphic sites.
  • This reduction is particularly substantial in regions with low crossing over.

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Conclusions:

  • Ancestral selective substitutions can decrease genetic diversity via hitchhiking.
  • The model predicts reduced polymorphism in low recombination regions due to strong selection.