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Soluble RAGEs - Prospects for treating & tracking metabolic and inflammatory disease

Ann Marie Schmidt1

  • 1Diabetes Research Program, Division of Endocrinology, Department of Medicine, New York University Langone Medical Center, 550 First Avenue, New York, NY 10016, United States.

Vascular Pharmacology
|July 2, 2015
PubMed

Insights

Soluble forms of the receptor for advanced glycation endproducts (RAGE) are linked to chronic diseases. These soluble RAGEs may serve as biomarkers for disease activity in metabolic and inflammatory conditions.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Immunology

Background:

  • The receptor for advanced glycation endproducts (RAGE) is implicated in tissue damage in chronic metabolic and inflammatory diseases.
  • Circulating levels of soluble RAGEs in human plasma/serum are reported as potential biomarkers.

Purpose of the Study:

  • To review the current understanding of soluble RAGEs.
  • To explore their formation, natural functions, and potential as biomarkers for disease activity.
  • To identify areas for future scientific investigation.

Main Methods:

  • Literature review of existing evidence on RAGE and soluble RAGEs.
  • Analysis of reports on RAGE in human subjects and disease pathogenesis.

Main Results:

  • Emerging evidence connects RAGE to the pathogenesis of tissue damage in chronic diseases.
  • Soluble RAGE forms in circulation may indicate the presence and extent of chronic disease.

Conclusions:

  • Soluble RAGEs are potential biomarkers for inflammatory and metabolic disease activity.
  • Further research is needed to fully elucidate the biology of soluble RAGEs and their clinical utility.
Keywords:
Soluble RAGE

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