Related Experiment Video

Updated: Apr 8, 2026

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
09:09

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

2.4K

Familial Mediterranean Fever With Complete Symptomatic Remission During Pregnancy

Kwang Taek Kim1, Hyun Joo Jang1, Jae Eun Lee1

  • 1Department of Internal Medicine, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea.

Intestinal Research
|July 2, 2015
PubMed

Insights

Familial Mediterranean fever (FMF), an autoinflammatory disease, can present in adulthood. This case highlights complete symptom remission during pregnancy in a Korean woman with FMF, offering insights into disease management.

Area of Science:

  • Genetics
  • Immunology
  • Internal Medicine

Background:

  • Familial Mediterranean fever (FMF) is an inherited autoinflammatory disorder caused by MEFV gene mutations.
  • It is characterized by recurrent fever, serositis, and is prevalent in Mediterranean populations.
  • Adult-onset FMF is less common, and its presentation can vary.

Purpose of the Study:

  • To report a rare case of adult-onset FMF in a Korean female patient.
  • To describe the unique presentation of complete symptomatic remission during pregnancy.
  • To discuss the implications for understanding FMF pathogenesis and management.

Main Methods:

  • Clinical case presentation and patient history.
  • Diagnostic evaluation including abdominal imaging and surgical history.
  • MEFV gene mutation analysis.

Main Results:

  • The patient experienced recurrent episodes of fever, abdominal pain, and vomiting.
  • Complete symptomatic remission of FMF was observed during pregnancy.
  • MEFV gene analysis identified two point mutations: p.Leu110Pro and p.Glu148Gln.

Conclusions:

  • This case demonstrates adult-onset FMF with pregnancy-related remission in an East Asian patient.
  • The findings suggest potential hormonal influences on FMF activity during pregnancy.
  • Further research is needed to elucidate the mechanisms behind pregnancy-induced remission in FMF.
Keywords:
Familial Mediterranean feverMEFV genePeriodic fever syndromePregnancy

Related Concept Videos

Methods of reducing fever01:22

Methods of reducing fever

The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
1.6K
Patterns of Fever01:26

Patterns of Fever

Before understanding the types and patterns of fever, it is essential to know its phases.
4.4K
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
451
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
30
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
1.1K
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
326