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Chromosomal localization of murine interleukin-1 alpha and beta genes
J Boultwood1, G Breckon, D Birch
1Leukaemia Research Fund Leukaemogenesis Laboratory, MRC Radiobiology Unit, Chilton, Didcot, United Kingdom.
Genomics
|October 1, 1989
Abstract:
DNA analyses of mouse X Chinese hamster somatic cell hybrids and of recombinant inbred mouse strains have previously shown that the interleukin-1 alpha and beta genes are tightly linked on murine chromosome 2, approximately 4.7 cM distal to beta-2-microglobulin. In this study, using in situ chromosome hybridization, we show that the two interleukin-1 genes are located in the F region of murine chromosome 2 and discuss this physical map position in relation to conserved genetic linkage groups.