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Extrahepatic comorbidities associated with hepatitis C virus in HIV-infected patients

Vicente Soriano1, Juan Berenguer

  • 1aHospital Universitario La Paz bInstituto de Investigación Sanitaria La Paz cHospital General Universitario Gregorio Marañón dInstituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.

Current Opinion in HIV and AIDS
|July 2, 2015
PubMed

Insights

HIV and hepatitis C virus (HCV) coinfection accelerates liver fibrosis. Extrahepatic manifestations of HCV are common in coinfected patients and may be reduced by antiviral therapy.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Immunology

Background:

  • HIV infection accelerates hepatitis C virus (HCV)-related liver fibrosis, increasing risks of cirrhosis and liver decompensation.
  • Extrahepatic manifestations of HCV significantly contribute to morbidity and mortality in chronic hepatitis C patients.
  • HCV primarily targets the liver, but its systemic effects are increasingly recognized.

Purpose of the Study:

  • To review current data on extrahepatic comorbidities associated with HCV in HIV-infected patients.
  • To understand the impact of HCV on non-liver related conditions in coinfected individuals.

Main Methods:

  • Literature review of current data on extrahepatic manifestations in HIV/HCV coinfection.
  • Analysis of studies examining comorbidities in coinfected populations.

Main Results:

  • A significant proportion of HIV/HCV coinfected individuals exhibit extrahepatic manifestations.
  • These manifestations include autoimmune disorders, lymphoproliferative diseases, and cardiovascular, renal, metabolic, and CNS issues.
  • Chronic immune activation and systemic inflammation in both HIV and HCV contribute to these comorbidities.

Conclusions:

  • Extrahepatic manifestations of HCV represent a substantial burden of morbidity and mortality in coinfected patients.
  • Successful antiviral therapy leading to HCV eradication may reduce both hepatic and extrahepatic manifestations.
Abstract

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