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Updated: Apr 7, 2026

A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting
Published on: May 16, 2013
[Pancytopenia, Hemolytic Anemia and Schizocytes: a Pragmatic Approach]
Nil Gökok1, Grégoire Stalder, Lorenzo Alberio
11 Service de médecine interne et Service d'hématologie, Département de Médecine, Centre Hospitalier Universitaire Vaudois, Lausanne.
Abstract:
A 58 year old woman presents with a progressive fatigue and dyspnea associated with paresthesia. Laboratory tests show pancytopenia with hypersegmented neutrophiles, macrocytic hyporegenerative anemia and arguments for hemolysis, in particular highly increased LDH. This constellation strongly suggests vitamin B12 deficiency, which was confirmed with an undetectable cobalamine concentration in the blood of our patient. The etiologic work up shows the presence of anti-parietal cells antibodies at a titer of 1/640, diagnostic of Biermer anemia.
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