Related Experiment Video
Updated: Apr 7, 2026
Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
The cellular immunity and oxidative stress markers in early pregnancy loss
Korkut Daglar1, Ebru Biberoglu1, Ayse Kirbas1
1a Department of Perinatology , Zekai Tahir Burak Women Health Care, Education and Research Hospital , Ankara , Turkey .
Objective:
We investigated whether changes in cellular immunity and oxidative stress in pregnancy have any association with spontaneous miscarriage.
Material And Methods:
Circulating adenosine deaminase (ADA) activity as a marker of cellular immunity and malondialdehyde (MDA) and catalase (CAT), glutathione peroxidase (GPx) as markers of T lymphocyte activation and parameters of oxidative stress and antioxidant defense were compared between 40 women with early pregnancy loss and another 40 women with ungoing healthy pregnancy.
Results:
Women with miscarriage had higher serum ADA and GPx levels when compared with women with normal pregnancy (p = 0.034 and p < 0.001, respectively). Although serum MDA level was slightly higher in women with miscarriage, the difference was not significant (p = 0.083). CAT levels were alike in both groups.
Conclusion:
We have demonstrated an increased cellular immunity and perhaps a compensated oxidative stress related to increased antioxidant activation in women with early spontaneous pregnancy loss.
