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Updated: Apr 7, 2026

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
Published on: November 28, 2019
Mast cell/MDSC a liaison immunosuppressive for tumor microenvironment
Luca Danelli1, Barbara Frossi2, Carlo E Pucillo2
1Department of Medical and Biological Science; University of Udine ; Udine, Italy ; Inserm UMRS-1149; CNRS ERL 8252; Laboratoire d'excellence INFLAMEX; Université Paris Diderot; Sorbonne Paris Cite ; Paris, France.
Abstract:
The instauration of an immunosuppressive microenvironment is a key event in cancer development and progression. Here, we discuss increasing evidences of the crosstalk between myeloid-derived suppressor cells (MDSCs) and mast cells (MCs) as a new fuel for the cancer immunosuppressive machinery.
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