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Displacement chromatography on cyclodextrin-silicas. II. Separation of cis-trans isomers in the reversed-phase mode
1Department of Chemistry, Texas A & M University, College Station 77843.
Journal of Chromatography
|December 22, 1989
Abstract:
The feasibility of preparative separations of cis-trans isomers by displacement chromatography on analytical-scale alpha-cyclodextrin-silica columns operated in the reversed-phase mode is demonstrated by using the isomers of 3-hexen-1-ol as model substrates and n-alkanols as displacers. The importance of matching the size of the cyclodextrin cavity and the solutes is shown. The crucial role of the displacer (both type and concentration) in the success of the displacement chromatographic separation is demonstrated.