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Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /T1Magnetic Resonance Imaging
Published on: November 20, 2018
Development of a multimodal imaging probe by encapsulating iron oxide nanoparticles with functionalized amphiphiles
Bo Yeun Yang1, Sung-Hyun Moon1, Sudhakara Reddy Seelam1
1Department of Nuclear Medicine & Institute of Radiation Medicine, Seoul National University College of Medicine, 110-799, Seoul, South Korea.
Aim:
We tried to develop a multimodal iron oxide nanoparticles (IO NP) imaging probe by an encapsulation method using specific amphiphiles for (68)Ga-labeling and lymph node-targeting.
Materials & Methods:
Nanoparticles (NPs) were encapsulated with a solution containing polysorbate 60 and the amphiphiles. The prepared NPs were labeled with (68)Ga and tested in vitro and in vivo.
Results:
Prepared 1,4,7-triazacyclononane-1,4,7-triacetic acid-IO-Mannose (NOTA-IO-Man) showed a narrow size distribution, and no significant aggregation or degradation under harsh conditions. The relaxivity coefficient of (68)Ga-NOTA-IO-Man was higher than that of ferumoxide. The accumulation of (68)Ga-NOTA-IO-Man in the lymph node after injection into rat's footpad was confirmed by both positron emission tomography and MRI.
Conclusion:
We successfully developed PET/MRI dual-modality imaging probe targeting lymph nodes by using the facile encapsulation method.
