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Is clinical tolerance possible after allergen immunotherapy?
Timothy P Moran1, A Wesley Burks
1Department of Pediatrics, The University of North Carolina School of Medicine, 104 Mason Farm Road Campus, Box 7310, Chapel Hill, NC, 27599-7310, USA, tmoran@email.unc.edu.
Current Allergy and Asthma Reports
|July 4, 2015
Summary
Allergen immunotherapy (AIT) shows promise for long-lasting allergy relief. However, achieving complete clinical tolerance, especially for food allergies, requires further research into assessment criteria and terminology.
Area of Science:
- Immunology
- Allergy Research
Background:
- Allergen immunotherapy (AIT) offers significant clinical benefits for allergic individuals.
- The induction of clinical tolerance, a persistent non-reactive state post-therapy, remains incompletely understood.
Purpose of the Study:
- To investigate whether AIT leads to clinical tolerance, particularly in food allergies.
- To address the knowledge gap regarding the long-term effects of AIT.
Main Methods:
- Review of studies assessing tolerance induction following AIT.
- Focus on oral immunotherapy studies for food allergies.
Main Results:
- Clinical tolerance is achievable in a subset of patients undergoing AIT.
- The equivalence of AIT-induced tolerance to natural tolerance in non-allergic individuals is yet to be determined.
Conclusions:
- Further research is needed to establish criteria for assessing tolerance induction.
- Standardized terminology is crucial for evaluating the disease-modifying potential of AIT.
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