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Splenectomy restores tumoricidal activity to promote elimination of intraocular tumors

Kyle C McKenna1

  • 1Department of Biology; Franciscan University of Steubenville ; Steubenville, OH USA.

Oncoimmunology
|July 4, 2015
PubMed

We recently demonstrated that splenectomy restores an interaction between CD8+ T cells and macrophages necessary for intraocular tumor elimination. Taking into consideration other studies indicating that intraocular tumor growth does not induce tumor-specific CD8+ T-cell tolerance, our data suggest that splenectomy may influence the phenotype of tumor-associated macrophages.

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