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Updated: Apr 7, 2026

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
Published on: March 17, 2020
Deficient regulatory B cells in human chronic graft-versus-host disease
Adèle de Masson1, Gérard Socié2, Martine Bagot1
1Service de Dermatologie; Hôpital Saint-Louis ; Paris, France ; INSERM UMRS 976; Laboratoire "Oncodermatology; Immunology and Cutaneous Stem Cells"; Université Paris VII Sorbonne Paris Cité; Hôpital Saint-Louis ; Paris, France.
Abstract:
Human chronic graft-versus-host disease (cGVHD) is a frequent and disabling complication of allogeneic hematopoietic stem cell transplantation. Regulatory B cells (Bregs) are IL-10-producing B cells that are able to inhibit the innate and adaptive immune responses. We have recently demonstrated a defect in regulatory B cells in human cGVHD.
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