Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Serum Laboratory Studies, Stool Test, Breath Test

Serum Laboratory Studies, Stool Test, Breath Test

Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Correction to: Treatment decision‑making in sickle cell disease patients.

Journal of community genetics·2021

Same author

Treatment decision-making in sickle cell disease patients.

Journal of community genetics·2021

Same author

Predictors of adverse psychological experiences surrounding genome-wide profiling for disease risk.

Journal of community genetics·2017

Same author

Recommendations for Telephone Counseling.

Journal of genetic counseling·2015

Same author

Attitudes towards Social Networking and Sharing Behaviors among Consumers of Direct-to-Consumer Personal Genomics.

Journal of personalized medicine·2015

Same author

Pre-screening education in multiple marker screening programs: The effect on patient anxiety and knowledge.

Journal of genetic counseling·2013

Search research articles

Related Experiment Video

Updated: Apr 7, 2026

Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development

Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development

Published on: May 17, 2024

Update and Review: Maternal Serum Screening.

¹Department of Pediatrics, University of Vermont College of Medicine, Burlington, Vermont.

Journal of Genetic Counseling

|July 5, 2015

Summary

Maternal serum screening using alpha fetoprotein (AFP), human chorionic gonadotropin (hCG), and unconjugated estriol (uE3) helps detect neural tube defects and chromosomal abnormalities. This review covers the latest advancements in prenatal screening and genetic counseling.

Area of Science:

Obstetrics and Gynecology
Prenatal Diagnosis
Biochemistry

Background:

Maternal serum marker screening is a key component of modern prenatal care.
Identifying specific biomarkers aids in assessing pregnancy risks.
Early detection of fetal anomalies is crucial for timely intervention.

Purpose of the Study:

To provide an updated overview of maternal serum screening protocols.
To discuss the utility of alpha fetoprotein (AFP), hCG, and uE3 in detecting fetal abnormalities.
To highlight the importance of genetic counseling in prenatal screening.

Main Methods:

Review of current literature on maternal serum screening.
Analysis of the diagnostic performance of AFP, hCG, and uE3.

More Related Videos

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

Published on: October 26, 2017

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Published on: December 5, 2015

Related Experiment Videos

Last Updated: Apr 7, 2026

Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development

Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development

Published on: May 17, 2024

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

Published on: October 26, 2017

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Published on: December 5, 2015

Discussion of genetic counseling strategies for high-risk pregnancies.

Main Results:

Maternal serum screening effectively identifies pregnancies at increased risk for neural tube defects and chromosomal aneuploidies like Down syndrome and Trisomy 18.
Combined analysis of AFP, hCG, and uE3 offers improved detection rates compared to single markers.
Genetic counseling is essential for informed decision-making and management.

Conclusions:

Maternal serum screening remains a valuable tool for prenatal risk assessment.
The integration of updated screening markers and genetic counseling enhances prenatal care.
Further research is needed to refine screening accuracy and expand its applications.