Inhibition of Protein Phosphatase 2A: Focus on the Glutamatergic System
Eduardo R Zimmer1, Antoine Leuzy2, Diogo O Souza1
1Department of Biochemistry, ICBS, Federal University of Rio Grande do Sul (UFRGS), 2600 Ramiro Barcelos Street, 90035-003, Porto Alegre, RS, Brazil.
Abstract:
In a recent review published in Molecular Neurobiology, Kamat and colleagues (Mol Neurobiol. 2014 Dec;50(3):852-65) highlighted the cellular and molecular mechanisms involved in Okadaic acid (OKA)-induced neurotoxicity. In this review, the authors underline a wide range of pathological signaling pathways involved in OKA-induced neurotoxicity; however, the role of glutamate was only briefly described. We believe that the hyperactivation of the glutamatergic system is a key pathophysiological player in OKA-induced neurotoxicity and deserves serious attention. In this commentary, we propose an integrative model linking glutamate and PP2A and put forward some unanswered questions.
More Related Videos
10:46Using Enzyme-based Biosensors to Measure Tonic and Phasic Glutamate in Alzheimer's Mouse Models
Published on: May 3, 2017
08:04Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
Published on: June 6, 2025
Related Concept Videos
Ligand-Gated Ion Channel Receptor: Gating Mechanism
GPCRs Regulate Adenylyl Cylase Activity
Antiepileptic Drugs: Glutamate Antagonists
GPCR Desensitization
Desensitization and Tachyphylaxis
Amplifying Signals via Enzymatic Cascade
