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Association of Venous Disorders with Leg Symptoms: Results from the Bonn Vein Study 1

M Wrona1, K-H Jöckel2, F Pannier3

  • 1Department of Dermatology, University of Bonn, Germany.

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
|July 5, 2015
PubMed

Insights

Venous disorders like varicose veins and chronic venous insufficiency are linked to leg symptoms such as itching and heaviness. These associations are stronger with more severe venous disease classifications.

Area of Science:

  • Vascular Medicine
  • Epidemiology
  • Public Health

Background:

  • Leg symptoms are common but their association with underlying venous disorders requires further population-based investigation.
  • The Bonn Vein Study 1 (BVS1) provides a valuable dataset for examining these relationships.

Purpose of the Study:

  • To investigate the association between diagnosed venous disorders and self-reported leg symptoms in a large population sample.
  • To determine which specific leg symptoms are most strongly correlated with chronic venous insufficiency (CVI) and varicose veins (VVs).

Main Methods:

  • A cross-sectional study of 2,624 participants (aged 18-79) from the Bonn Vein Study 1.
  • Clinical and duplex investigations were used to diagnose CVI and VVs (CEAP classification).
  • Leg symptoms were assessed via standardized interviews, and logistic regression analyzed associations.

Main Results:

  • Higher prevalence of leg symptoms was reported by women and increased with age and BMI extremes.
  • Varicose veins (22.6%) and CVI (15.8%) were significantly associated with reporting leg symptoms.
  • Itching, heaviness, tightness, swelling, and pain after standing/sitting showed positive associations with VVs and CVI.

Conclusions:

  • Venous disorders are significantly associated with multiple leg symptoms, particularly itching, heaviness, and tightness.
  • The severity of venous disease (CEAP C2 and above) correlates with the presence of these symptoms.
  • These findings highlight the importance of considering venous disorders in patients presenting with leg symptoms.
Abstract

Keywords:
CEAPChronic venous insufficiencySymptomsVaricose veinsVenous disorders

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