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Related Concept Videos

Microbiome of the Eye01:22

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In Vivo Confocal Microscopy in the Diagnosis and Management of Dry Eye: A Focus on Imaging Protocols and Interpretation
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[Ligneous conjunctivitis].

M Bauer1, S Koinzer2, I Oschlies3

  • 1Klinik für Ophthalmologie, UKSH, Campus Kiel, Arnold-Heller-Str. 3, 24105, Kiel, Deutschland. maya.bauer@uksh.de.

Der Ophthalmologe : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft
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PubMed
Summary
This summary is machine-generated.

This case report details a 3-year-old with ligneous conjunctivitis and plasminogen deficiency. A novel combination therapy including fresh frozen plasma (FFP) eye drops and cyclosporine A achieved stable disease control.

Keywords:
Cyclosporine AFibrinFresh frozen plasmaGranulation tissuePlasminogen

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Area of Science:

  • Ophthalmology
  • Hematology
  • Genetics

Background:

  • Ligneous conjunctivitis is a rare, recurrent inflammatory condition of the conjunctiva.
  • It is often associated with a deficiency in serum plasminogen, a key protein in the fibrinolytic system.
  • This condition typically presents in childhood and can lead to significant ocular morbidity.

Observation:

  • A 3-year-old female presented with recurrent conjunctivitis and characteristic membrane formation on the upper eyelid.
  • Histopathological examination post-surgical removal confirmed ligneous conjunctivitis.
  • Laboratory analysis revealed a manifest serum plasminogen deficiency of 22%.

Findings:

  • The patient was treated with a combination of corticosteroids, heparin-containing eye drops, and fresh frozen plasma (FFP) eye drops.
  • Surgical ablation was performed, with perioperative intravenous FFP administration.
  • Local cyclosporine A eye drops were also administered, leading to a stable condition with low disease activity.

Implications:

  • This case highlights a novel therapeutic strategy for ligneous conjunctivitis, combining medical and surgical interventions.
  • The successful use of fresh frozen plasma (FFP) eye drops and cyclosporine A represents a new treatment approach.
  • This combined therapy, previously undescribed, offers a potential avenue for managing this rare and debilitating condition.