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A Strategy for Sensitive, Large Scale Quantitative Metabolomics
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Updating the Cornell Net Carbohydrate and Protein System feed library and analyzing model sensitivity to feed inputs
R J Higgs1, L E Chase1, D A Ross1
1Department of Animal Science, Cornell University, Ithaca, NY 14853.
Journal of Dairy Science
|July 6, 2015
Summary
The Cornell Net Carbohydrate and Protein System (CNCPS) model was updated with new ingredient data and analytical methods for more precise animal nutrition predictions. These improvements enhance the accuracy of dietary energy and protein supply calculations in animal production systems.
Area of Science:
- Animal Nutrition
- Nutritional Modeling
- Agricultural Science
Background:
- The Cornell Net Carbohydrate and Protein System (CNCPS) is a widely used nutritional model for animal production.
- Accurate ingredient composition data is crucial for effective diet formulation.
- Previous versions may have had limitations in predicting nutrient supply.
Purpose of the Study:
- To update and refine the CNCPS feed library with contemporary data.
- To improve the prediction accuracy of dietary energy and protein supply.
- To enhance the model's biological description and user-friendliness.
Main Methods:
- Evaluation of approximately 800 feed ingredients against commercial laboratory data.
- Development of a multistep approach (linear regression, matrix regression, optimization) for predicting uncertain values.
- Reclassification of the protein A fraction to ammonia and updating amino acid profiles.
Main Results:
- The updated CNCPS feed library provides more precise predictions of dietary energy and protein.
- Model sensitivity analyses indicated metabolizable energy prediction is sensitive to feed chemistry, and metabolizable protein to digestion rates.
- The reclassification of protein A and updated amino acid profiles improve predictions of metabolizable protein.
Conclusions:
- Updates to the CNCPS feed library enhance its utility for formulating animal rations.
- The refined model offers a more accurate description of nutrient supply and animal requirements.
- While on-farm analysis is recommended, the updated library serves as a robust platform for ration formulation.

