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Updated: Apr 7, 2026

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
Published on: January 31, 2025
Necrobiosis Lipoidica
Cathryn Sibbald1, Sophia Reid2, Afsaneh Alavi1
1Department of Medicine (Dermatology), University of Toronto, Toronto, Ontario, Canada.
Abstract:
Necrobiosis lipoidica is a granulomatous condition presenting as indolent atrophic plaques, often on the lower extremities. There is a multitude of case reports suggesting possible associations and documenting different therapeutic alternatives with varied success. Important complications include ulceration and the development of squamous cell carcinoma. The disease course is often indolent and recurrent despite treatment. This article reviews the etiopathogenesis, clinical presentations, and evidence for treatment alternatives of this condition.
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