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Updated: Apr 7, 2026
Assessment of Viability of Human Fat Injection into Nude Mice with Micro-Computed Tomography
Published on: January 7, 2015
Autologous fat augmentation of the vocal fold with basic fibroblast growth factor: Computed tomographic assessment of
Etsuyo Tamura1, Yasuhiko Tabata2, Chizumi Yamada3
1a 1 Department of Otorhinolaryngology, Tokai University School of Medicine, Tokai University Tokyo Hospital , Tokyo, Japan.
Conclusion:
The volume of fat tissue loss after vocal fold augmentation can be decreased when augmentation is performed with addition of basic fibroblast growth factor (b-FGF).
Objectives:
The effectiveness of augmentation is easily decreased due to absorption. Canine experiments have confirmed that the decreased effectiveness caused by absorption after augmentation can be reduced by administering low-concentration b-FGF. Clinical application was trialed after acquiring approval from the institutional clinical review committee.
Method:
Autologous fat tissue with b-FGF was injected into the vocal folds in cases of unilateral vocal cord paralysis. This study compared fat tissue survival after injection by assessing images from computed tomography (CT).
Results:
Assessments using CT revealed that the decrease in volume of injected fat tissue was smaller in cases treated using b-FGF than in cases using the conventional method. No severe complications were encountered using this method.
