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Hyperbaric oxygen therapy for refractory radiation-induced hemorrhagic cystitis
Tiago M Ribeiro de Oliveira1,2, António J Carmelo Romão2, Francisco M Gamito Guerreiro1
1Underwater and Hyperbaric Medicine Center, Portuguese Navy, Lisbon, Portugal.
Hyperbaric oxygen therapy effectively treats radiation-induced hemorrhagic cystitis, with 89.8% of patients experiencing hematuria resolution. Success correlates with transfusion needs and session count, demonstrating a safe and viable treatment option.
Area of Science:
- Urology
- Oncology
- Hyperbaric Medicine
Background:
- Radiation therapy can cause radiation-induced hemorrhagic cystitis, a debilitating condition.
- Refractory cases present a significant clinical challenge, often requiring advanced treatment modalities.
Purpose of the Study:
- To evaluate the efficacy of hyperbaric oxygen therapy (HBOT) for radiation-induced hemorrhagic cystitis.
- To identify predictors of successful HBOT outcomes in this patient population.
Main Methods:
- Retrospective analysis of 176 patients with refractory radiation-induced hemorrhagic cystitis treated with HBOT.
- Efficacy assessed by macroscopic hematuria resolution, correlated with clinical variables.
Main Results:
- HBOT achieved hematuria resolution in 89.8% of patients after an average of 37 sessions.
- Adverse events were minimal (1.7%).
- Hematuria resolution was significantly associated with prior transfusion therapy and the total number of HBOT sessions.
Conclusions:
- Hyperbaric oxygen therapy is a safe and effective treatment for refractory radiation-induced hemorrhagic cystitis.
- Treatment success is linked to transfusion requirements and treatment duration (number of sessions).
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