Related Experiment Video
Updated: Aug 18, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Collagen corneal shields enhance penetration of topical prednisolone acetate
M R Sawusch1, T P O'Brien, S A Updegraff
1Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Baltimore, Maryland.
Abstract:
We used an animal model to compare the corneal and aqueous penetration of topical prednisolone acetate 1% with and without the presence of a commercially available collagen corneal shield. A significant (P less than .02) increase in penetration into cornea and aqueous humor at 30 minutes and 120 minutes was found in eyes with a collagen corneal shield in place. Increased concentrations were achieved by soaking the shield in prednisolone acetate for 15 minutes prior to application.

