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The right drugs at the right time for the right patient: the MD Anderson precision oncology decision support platform

Amber Johnson1, Jia Zeng1, Ann M Bailey1

  • 1Sheikh Khalifa Al Nahyan Ben Zayed Institute for Personalized Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Drug Discovery Today
|July 8, 2015
PubMed

Insights

Clinical interpretation of cancer genetic alterations needs better support. The precision oncology decision support (PODS) platform bridges the gap between detecting molecular changes and choosing optimal cancer treatments.

Area of Science:

  • Oncology
  • Bioinformatics
  • Genomics

Background:

  • Technical advances in detecting cancer-associated genetic alterations have outpaced the development of clinical interpretation resources.
  • Lack of decision support for oncologists leads to inaction or suboptimal treatment choices, impacting patient outcomes and clinical trial research.

Purpose of the Study:

  • To describe the precision oncology decision support (PODS) platform.
  • To bridge the gap between molecular alteration detection and the identification of appropriate cancer therapies.

Main Methods:

  • Development of the PODS platform at The Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy (IPCT).
  • Focus on integrating molecular data with clinical decision-making.

Main Results:

  • The PODS platform facilitates the clinical interpretation of cancer-associated genetic alterations.
  • The platform aids in identifying appropriate treatments based on molecular profiles.

Conclusions:

  • The PODS platform addresses the critical need for clinical decision support in precision oncology.
  • Implementing PODS can improve patient outcomes and streamline cancer research by enabling evidence-based therapeutic decisions.

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