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Trabecular bone score in healthy ageing.

A Bazzocchi1, F Ponti2, D Diano2

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Summary
This summary is machine-generated.

This study establishes reference Trabecular Bone Score (TBS) values for healthy Italians, showing TBS and bone mineral density decrease with age. These findings aid in assessing bone health and monitoring changes.

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Area of Science:

  • Bone densitometry and osteoporosis research.
  • Radiology and medical imaging analysis.
  • Human physiology and aging studies.

Background:

  • Trabecular Bone Score (TBS) offers insights into bone microarchitecture beyond bone mineral density (BMD).
  • Establishing reference standards is crucial for accurate clinical interpretation of TBS.
  • Previous studies have explored TBS in various populations, but Italian-specific data is needed.

Purpose of the Study:

  • To establish age- and sex-specific reference curves for Trabecular Bone Score (TBS) in a healthy Italian population.
  • To serve as a reference standard for future clinical and research applications.
  • To investigate the correlations between TBS and conventional dual-energy X-ray absorptiometry (DXA) parameters, including bone composition and body composition.

Main Methods:

  • Prospective recruitment of 250 healthy Italian individuals aged 18-70, equally distributed by age and sex.
  • Acquisition of lumbar spine (LS) DXA scans analyzed using TBS iNsight software v. 2.1.
  • Collection of LS bone mineral density (LS BMD), Z-score, T-score, and TBS values, with Pearson's test for correlation analysis.

Main Results:

  • Significant age-related decreases in both TBS and LS BMD were observed in males and females.
  • A strong positive correlation was found between LS BMD and TBS across both sexes.
  • Body Mass Index (BMI) affected LS BMD but not TBS, while TBS showed an inverse correlation with visceral adipose tissue.

Conclusions:

  • This study provides initial age- and sex-specific reference curves for TBS in healthy Italians.
  • These reference values can assist clinicians in improving patient management for bone mineral status.
  • The findings contribute to a better understanding of TBS in relation to bone and body composition in the Italian population.