Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Coagulation01:06

Coagulation

1.7K
Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
1.7K
Coagulation01:09

Coagulation

12.1K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
12.1K
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

15.6K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
15.6K
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

466
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
466
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

473
IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
473
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

15.8K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
15.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Delivery of Oral Health Services at Medical Visits through 3 Medical Dental Integration Models.

JDR clinical and translational research·2024
Same author

Response of diademed sifaka (<i>Propithecus diadema</i>) to fosa (<i>Cryptoprocta ferox</i>) predation in the Betampona Strict Nature Reserve, Madagascar.

Ecology and evolution·2024
Same author

Analytical performance evaluation of two automated urine chemistry analysers using two levels of commercially available quality control material.

The Journal of small animal practice·2023
Same author

Analytical performance evaluation of two automated urine sediment analysers using two levels of commercially available quality control material.

The Journal of small animal practice·2023
Same author

Canine Cutaneous Plasmacytosis: 21 Cases (2005-2015).

Journal of veterinary internal medicine·2017
Same author

Reformulations of well-known active ingredients in the topical treatment of psoriasis vulgaris can improve clinical outcomes for patients.

Journal of the European Academy of Dermatology and Venereology : JEADV·2017
Same journal

RNA Sequencing Indicates Distinct Platelet Transcriptomic Changes in Immune Thrombocytopenia.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

Joint effect of muscle strength and physical inactivity on risk of incident venous thromboembolism: The Tromsø Study.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

The Natural Mutation Arg221aTrp in Human α-Thrombin Abrogates Physiological Na<sup>+</sup> Binding and Preferentially Hinders the Protease Anticoagulant Functions.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

A historical review of the biological, semantic and clinical aspects of aspirin resistance.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

Association between Thrombus Neutrophil Extracellular Traps Content and Ischemic Stroke Recurrence.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

Peptide-Mediated Inhibition of Surface-Initiated Thrombogenesis.

Journal of thrombosis and haemostasis : JTH·2026
See all related articles

Related Experiment Video

Updated: Apr 7, 2026

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
04:56

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Published on: August 4, 2023

1.4K

TACTIC: Trans-Agency Consortium for Trauma-Induced Coagulopathy.

K G Mann1, K Freeman2

  • 1Department of Biochemistry, University of Vermont, Colchester, VT, USA.

Journal of Thrombosis and Haemostasis : JTH
|July 8, 2015
PubMed
Summary
This summary is machine-generated.

Trauma-induced coagulopathy (TIC) presents complex challenges due to varied causes and limited diagnostics. Research focuses on understanding TIC mechanisms and developing new diagnostic tools for better acute treatment strategies.

Keywords:
blood coagulation disordersendotheliumhemorrhageplateletsthrombintrauma

More Related Videos

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.8K
Integrated Compensatory Responses in a Human Model of Hemorrhage
07:57

Integrated Compensatory Responses in a Human Model of Hemorrhage

Published on: November 20, 2016

13.2K

Related Experiment Videos

Last Updated: Apr 7, 2026

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
04:56

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Published on: August 4, 2023

1.4K
Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.8K
Integrated Compensatory Responses in a Human Model of Hemorrhage
07:57

Integrated Compensatory Responses in a Human Model of Hemorrhage

Published on: November 20, 2016

13.2K

Area of Science:

  • Trauma and Emergency Medicine
  • Hematology
  • Translational Science

Background:

  • Trauma-induced coagulopathy (TIC) is a complex condition with diverse underlying causes.
  • Current diagnostic tests are insufficient to differentiate TIC subtypes in acute settings, hindering effective treatment.
  • Understanding TIC mechanisms is crucial for developing targeted therapies.

Purpose of the Study:

  • To provide an overview of progress in understanding TIC mechanisms.
  • To outline hypotheses for the TACTIC initiative focused on early translation of research findings.
  • To explore advancements in diagnostics and computational analysis for TIC.

Main Methods:

  • Review of current understanding of TIC mechanisms.
  • Description of the TACTIC initiative's focus on early translational research.
  • Identification of novel analytes and biomarkers for coagulation assessment.
  • Evaluation of viscoelastic tests and point-of-care diagnostic methods.

Main Results:

  • Progress in elucidating the complex mechanisms of TIC.
  • Identification of key areas for early translational research in TIC.
  • Focus on novel biomarkers including tissue factor, polyphosphates, histones, and activation complexes.
  • Assessment of advanced diagnostic techniques like viscoelastic tests and point-of-care methods.

Conclusions:

  • Further research into TIC mechanisms is essential for improving patient outcomes.
  • Development of novel diagnostic scoring systems and biomarkers is a key translational goal.
  • Advancements in analytical methods will aid in discriminating TIC subtypes for tailored treatment.