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B-1 phagocytes: the myeloid face of B-1 cells

Ana Flavia Popi1

  • 1Department of Microbiology, Immunology, and Parasitology, Federal University of São Paulo, São Paulo, Brazil.

Annals of the New York Academy of Sciences
|July 8, 2015
PubMed

The relationship between malignant B cells and macrophages has long been established. Furthermore, evolutionary studies have demonstrated that B cells from early vertebrates have both phagocytic and antibody production capabilities. In addition to their lymphoid nature, B-1 cells retain several myeloid characteristics. Various reports have demonstrated that B-1 cells can differentiate into phagocytes. However, descriptions of B-1 cells as a novel phagocyte cell member are rarely found in the literature. This review aims to present the available data regarding B-1 cell-derived phagocytes and also discusses how their existence might be relevant to hematopoiesis and immune responses.

Keywords:
B-1 cellslymphoidmyeloidphagocytosis

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