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Related Concept Videos

Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

327
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
327
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

358
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
358
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

814
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
814
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

336
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
336
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

348
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
348
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

321
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
321

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Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
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Nutraceuticals for geriatrics.

Charu Gupta1, Dhan Prakash1

  • 1Amity Institute for Herbal Research & Studies, Amity University UP, Noida, India.

Journal of Traditional and Complementary Medicine
|July 8, 2015
PubMed
Summary

This review highlights phytochemicals for healthy aging in older adults. It emphasizes nutrition

Area of Science:

  • Geriatric Medicine and Nutrition Science
  • Nutraceuticals and Healthy Aging Research

Background:

  • Aging populations globally face increased risks of chronic diseases like hypertension, diabetes, and dementia.
  • Older adults are vulnerable to micronutrient deficiencies due to various socioeconomic and physical challenges.
  • Decreased immunity in the elderly exacerbates morbidity and mortality from infections, with nutritional status being a key factor.

Purpose of the Study:

  • To review the role of phytochemicals in promoting healthy aging.
  • To identify nutraceutical compounds beneficial for the geriatric population.
  • To underscore the importance of dietary interventions in preventing age-related chronic illnesses.

Main Methods:

  • Literature review focusing on phytochemicals and their impact on aging.
Keywords:
aginggeriatricshealthnutraceuticalnutritionphytochemicals

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  • Analysis of nutritional challenges faced by the elderly.
  • Synthesis of current research on dietary interventions for geriatric health.

    • Main Results:

    • Phytochemicals show promise in mitigating age-related chronic diseases and supporting immune function.
    • Targeted nutritional strategies can address deficiencies common in older adults.
    • Healthy lifestyle practices, particularly diet, are crucial for preventing age-associated decline.

    Conclusions:

    • Phytochemicals represent a significant area for developing interventions to promote healthy aging.
    • Addressing nutritional status is vital for improving health outcomes in the geriatric population.
    • Further research into nutraceuticals is warranted to support functional independence and well-being in older adults.