Related Experiment Video
Updated: Oct 22, 2026

Generation of Patient-Derived Podocytes from Skin Biopsies
Published on: May 26, 2023
Abnormal ER-Golgi vesicular trafficking leads to podocyte detachment
Yangyang Niu1, John Cijiang He2
1Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Department of Nephrology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Abstract:
Podocyte detachment represents a point of no return in the progression of proteinuric kidney diseases, yet the molecular mechanisms driving this process remain poorly understood. In this issue of Kidney International, Imai et al. report that suppression of N-ethylmaleimide-sensitive factor, a key regulator of endoplasmic reticulum-to-Golgi vesicular trafficking, contributes to impaired integrin maturation and podocyte detachment. These findings establish, for the first time, a critical role for endoplasmic reticulum-to-Golgi vesicular trafficking in maintaining podocyte integrity.
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